Assessing human exposure to toxic metals and their potential health effects continues to be a matter of public concern with increasing awareness of potentially toxic metals concentrations to be present in many products including infant formula, fruit juice, consumable products containing rice, fish, vaccines, and toys, as well as in some occupational and residential environments. An ever-increasing demand for definitive answers has prompted body burden studies across the country.
Metal speciation in biomonitoring has a significant role because a metal’s valence state and molecular form frequently dictates its availability for uptake into the human body and the subsequent potential for deleterious effects.
For more than a decade, Brooks Applied Labs has been providing services for analytical method development and specialized analyses for trace metals and metal species in a variety of human tissues and fluids including:
- synovial fluid
- gastrointestinal fluid
- fingernails and toenails
Over the years, Brooks Applied Labs has developed a number of analytical methods to overcome the common issues and interferences normally associated with analyzing these complex matrices. The laboratory staff at Brooks Applied Labs is also fully trained in the safe handling of potentially infectious materials and is a Biosafety Level 2 (BSL-2) laboratory.
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Biomonitoring Public Projects
Method Related Work
BAL also has a number of studies that have been funded both internally and externally with the goal of developing new methods and improving existing methods for the accurate and precise quantification of low-level trace metals in urine, hair, and blood samples. BAL has published and/or presented the following work related to the methods that are proposed for metals analysis in hair, urine and blood samples:
Total cobalt determination in human blood and synovial fluid using inductively coupled plasma-mass spectrometry: method validation and evaluation of performance variables affecting metal hip implant patient samples
Identification and mitigation of preparatory and analytical biases were investigated to maximize confidence in results reported to physicians supporting revision surgeries.
Download the Scientific Article Published in the Journal Toxicological & Environmental Chemistry
A Comparative Study of Analytical Methods for the Determination of Trace Metals in Blood using ICP-MS
The focus of this study was to determine a simple and precise technique for the analysis of multiple trace elements in whole blood.
Download the Comparative Study of Sample Dilution Techniques for the Analysis of Trace Metals in Whole Blood poster
Optimization of an Analytical Method for the Determination of Trace Levels of Cr, Ni, Fe, and V in Urine Samples Using ICP-DRC-MS
Urine samples from individuals known to be occupationally exposed to particulate metal fumes were analyzed with methods developed by Brooks Applied Labs and optimized to provide accurate and quantifiable results at low parts-per-trillion concentrations.
Download the Simultaneous Determination of Stainless Steel Components in Urine Samples Using ICP-DRC-MS poster
Determination of Methylmercury in Human Hair: A Comparison of Digestion Methods
Brooks Applied Labs Analyzed human hair samples to evaluate and compare the effectiveness of two methods of digestion for methylmercury analysis.
Download the Determination of Methylmercury in Human Hair: A Comparison of Digestion Methods Report