Micronutrient Optimization

Production yield directly equates to profitability for biopharmaceutical production.  This is a simple fact which has necessitated process optimization investigations throughout the industry. Emphasis regarding bioreactor optimization historically has focused on bulk nutrients such as carbon, nitrogen, and phosphorous sources but also included growth conditions (pH, temperature, agitation, continuous versus batch additions, etc.).  Biopharmaceutical companies are increasingly being educated that micronutrients can play as key of a role as bulk nutrients due to their biochemical interactions during the metabolic processes. Brooks Applied Labs supports this process via analytical services to input the best available data into optimization models to maximize your company’s potential not just to generate biopharmaceutical but also to ensure the viability of the processes for the future.

Biopharmaceutical companies are increasingly being educated that micronutrients can play as key of a role as bulk nutrients due to their biochemical interactions during the metabolic processes.

Design of experiments play a key role in reducing resource expenditures including: time, analytical costs, experimentation costs, and interpretation of data. By altering more than one variable at a time micronutrient optimization can be achieved with much greater efficiency. A logical approach starting with defining the number of variables is recommended (we can help with that too!). Once the variables are established a statistical model can be adopted which will drive the data matrix and, ultimately, the number of data points (samples that require analyses).

Statistical Model Designed

The benefits for taking a strategic design of experiments (DOE) for micronutrient optimization are twofold: greater yield equating to increased profitability and identifying acceptance criteria prior to production. While greater yield is always desirable the second variable of acceptance criteria is not often established which can ultimately have greater impacts on the bottom line.

Encountering out of specification (OOS) events, especially on a consistent basis, can be extremely costly for both your company and the effected patients. Incorporation of the optimized micronutrient levels in your quality systems mitigates this risk.

The value prospective for micronutrient optimization in biological production processes is significant effecting multiple aspects of the profit margins. Whether you are associated with a small or large biopharmaceutical company the cost to support optimization will always be outweighed by the benefit. Contact us today to embark on your voyage to more robust and profitable systems.