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Pharmacokinetic Clinical Studies: Improving People’s Lives

The biological significance of metals from both pharmaceutical drug discovery and production aspects has increased significantly over the past two decades. Integration of trace metals in complex pharmaceuticals, both small and large molecule, can play a key role in their viability as well as their stability. Furthermore, active sites on organic molecules will dictate their adsorptive properties (“stickiness” to the outside of the molecule) for trace metals, which can also impact clinical efficacy. Brooks Applied Labs has a long history of supporting both the prevention and cure for cancers and other human ailments through research, consulting, and analytical services.

Pharmaceutical companies, academic institutions, and international scientific consortiums have relied upon Brooks Applied Labs to deliver high quality, defensible analytical results for drug discovery, delivery, production, stability, and efficacy. Our proprietary methods target total elemental composition of materials, as well as their molecular forms, using advanced analytical equipment (such as ICP-MS/MS) coupled to chromatographic systems. A short list of web links has been provided below, representing just a few of our collaborative efforts.

One of the highlights of our efforts has been working with a consortium of concerned scientists to address the arsenicosis issue that affects the inhabitants in Bangladesh. It has been well documented that the drinking water sources for rural areas in Bangladesh contain very high concentrations of arsenic. Certain molecular forms of selenium were identified to chemically interact with arsenic in the human body to produce a selenium-arsenic adduct that is more readily excreted in the urine; thus, reducing the carcinogenic effects. BAL continues to support research efforts to alleviate the impacts of arsenicosis throughout the world.

Quality control and conformance to regulatory requirements are of utmost importance in establishing defensibility and maximizing confidence in all results released by BAL. Furthermore, BAL takes it one step further with conformance to scientific principles which can contradict promulgated methods and publications. We are on the forefront of technology for analytical chemistry and applied metalloid research, as we take it upon ourselves to better scientific principles and educate those in need through webinars, presentation at scientific conferences, and workshops.

Our preventative efforts to combat cancer and other ailments have been in the form of testing the environment around all of us on a relatively holistic basis. BAL’s partnership with the food, environmental, power generation, petroleum processing, mining, and other markets have mitigated exposure to trace metals and metalloid compounds internationally. By understanding not just how much of an element is present in a material, but also the molecular form, the risk assessment and remediation efforts are more focused and efficient. Our proprietary methods provide the technological advancements that make our air, water, soil, food, and products safer for the current and coming generations.

Whether your goal is to reduce or eliminate the risk of health concerns associated with metals and metalloid compounds before exposure to humans, or to treat ailments after manifestation, Brooks Applied Labs is excited to partner with you. Partnering with BAL goes beyond selecting a laboratory, as we are most often perceived as a valuable teammate called upon to solve the most challenging problems. Contact us to find out how we can help you with your next clinical or pharmacokinetic study.

https://clinicaltrials.gov/ct2/show/NCT02377635
https://gsa.confex.com/gsa/2014AM/webprogram/Paper250076.html
https://gsa.confex.com/gsa/2008AM/finalprogram/abstract_149365.htm
http://pubs.rsc.org/en/content/articlelanding/2017/mt/c7mt00201g#!divAbstract
https://pqdtopen.proquest.com/doc/894949380.html?FMT=ABS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705316/

Traveling in Cuba to Learn about Cuban Women’s Lives

A chemist from Brooks Applied Labs recently traveled with a group to Cuba for two weeks, and she shared her experiences during this fascinating adventure with us. It was an exciting opportunity to connect with Cubans to learn what life is like there for many people, with a focus on the lives and roles of women in Cuba. Brooks Applied Labs values our diverse staff with rich backgrounds and experiences. We believe that having employees who can bring varied perspectives together allows for an incredible, inclusive culture that fosters limitless learning opportunities.

To experience a slice of Cuban childhood and education firsthand, the group was able to visit a large primary school for grades 1-8. She found the breadth of studies available to be impressive. “It was a huge school. They had a zoo with animals like a monkey, a crocodile… there was an agricultural farm.” She explained how the zoo was a part of the curriculum, with classes teaching biology and how to care for the animals. The school put on a dance performance for the visiting Americans to demonstrate their arts program, which teaches dance, singing, musical instruments, visual arts, and more. “Seeing how confidently they were [dancing] was really amazing. Our group was crying at the end of the experience.”

A visit to a maternity clinic provided insight on the healthcare available to women in Cuba. According to UN World Population Prospects, the infant mortality rate in Cuba has dropped drastically in the past half-century, with rates now lower than the United States. Many of the women were from rural areas and were staying at the clinic because of its focus on chronic illnesses such as diabetes. Women in every region have access to these specialized maternity clinics.

The group visited small towns and rural areas, and met with the about 50 women in leadership positions at an agricultural co-op. “They were very happy to meet us and welcomed us with food and coffee that they had produced. They wanted to get to know us, too.” They explained that one purpose of the co-op is for farmers to be able to share machinery. Instead of each of the many farmers buying his or her own tractor, they are able to share a few within the co-op. The co-op also helps with loan assistance, pools resources, and provides many other services for the community.

The women they met hold many different positions from finance management to agricultural engineering, and the women there held a majority of the leadership positions of the co-op. This was important to see, she explained, because “without a co-op, these leadership roles don’t exist, so it helped cultivate positions for women and gave them the opportunity to step into a leadership role.  In turn, you now have a co-op that mainly women are running.”

Stepping a bit further from the city and small towns, she was able to enjoy the natural beauty that Cuba has to offer as well, summiting the highest peak in Cuba, Pico Turquino. It may have been challenging – it was a 26-km hike over three days – but she explained how much she enjoyed it. “It was really cool… we got to be in nature and see the biological diversity in the tropics. It’s very dense.  There are a lot of birds, a lot of bird watching” Her favorite? The beautifully colorful national bird of Cuba, “called the Tokororo (pictured), because that’s the noise it makes!”

Now back in Seattle, she is excited to share her observations and experiences with the community at home. We are glad to have her back with us at Brooks Applied Labs and are very grateful for the chance for all of us to learn more about Cuba!

Want to Work at a Thriving Company That Values Your Values?

Part of BAL’s vision is to support better environmental, human health, and scientific decision-making in a workplace that honors your core values. We don’t just post this on the wall of the lobby, we live it every day and love what we do, who we work with, and where we call home. Whether you desire a career as a renowned analytical chemist, a rock-star project manager, a quality assurance guru, or a business development professional, BAL has great opportunities for both entry-level and experienced candidates. See our Careers page to find out more about how you can be a part of our amazing team.

BAL Donates 120 Pounds of Food to Sultan Food Bank

Each holiday season, Brooks Applied Labs collects food for a local food drive. This year our office provided 120 pounds of food for hungry families in a rural part of our region. A big thank you to Jen Wallawine (BAL’s Inventory Management Specialist) and her husband for coordinating the donation bins and delivering everything to the Sultan Food Bank.